胚胎时差培养箱Embryoscope基于其强大的决策支持工具KID Score D3和KID Score D5模型，通过胚胎的形态学及形态动力学，对胚胎进行筛选评分，选择优质的胚胎进行冷冻或者移植。胚胎形态学包括多核化，细胞碎片化，细胞分裂均匀度等，其中囊胚的形态学是KID Score D5模型中的重要指标，主要通过评估囊胚的扩张程度（发育速度），卵裂形态和碎片等情况可初步筛选出相对优质的囊胚，下文即为基于囊胚的形态学（扩张程度）与其整倍性，妊娠率等的相关性研究：
Blastocyst contractions are strongly related with aneuploidy, lower implantation rates and slower embryo cleavage timing: time lapse study
E Gazzo1, F Peña1, F Valdéz2, A Chung1, M Velit1, M Ascenzo1, E Escudero1
1Clínica de Fertilidad INMATER, Lima, Peru. 2Genomics Peru, Lima, Peru.
Objectives: We set out to identify contraction (CT) patterns in human blastocyst and their correlation with their ploidy status (PGT-A analysis), the time they took to reach blastocyst and the pregnancy rate.
Methods: Design: Retrospective study. 912 embryos from 270 patients that went through our center were evaluated. All embryos were cultivated in the Embryoscope incubator. From 912 embryos that started the cohort, 778 were tested for aneuploidy using an NGS platform in a reference laboratory. Blastocyst contractions (CT) were evaluated using the "embryo drawing tool" to obtain the CT percentage. 182 SET were performed, and the mean patient age was 30.44 years, ranging from 24 to 39 years.
Results: Embryos was divided in two groups, those that contracted (CT) and those that did not, we call them "solo expanding" (SE). When this was compared to ploidy status the embryos that SE showed 58.33% to be euploid while 53.58% of embryos that CT where aneuploid. This was statistically significant (p=0.029) showing that embryos that don't contract SE have higher chances of being euploid that embryos that contract CT. When we compared pregnancy rates, we also saw an increase in embryos that SE (63.10%) with embryos that CT (46.67%), this was also statistically significant (p=0.012). Finally, we saw that embryos that CT take longer to reach blastocyst stage compared to SE embryos. This also was significant (p=0.004). Finally we evaluated if the patients age an impact on whether the embryo was CT or SE and found no difference, showing that age should not be a factor y embryo contraction.
Conclusion: The results in this study show statistically significance in two analyzed traits. We showed that CT embryos show a higher chance of being aneuploid, and that they have a lower implantation rate. Also, we showed that embryos that CT take longer to reach blastocyst stage. All this was showed to happen regardless of maternal age. This proves that looking for embryo contractions could be helpful for selecting an embryo for transfer.